Thread 16805938

Hi /sci/, what is the best and current understanding on the down-regulation of dopamine / serotonin receptors?

As someone with depression for 5 years now, I've really narrowed it down to having to do with the sensitivity of dopamine receptors. After being flooded and burned for years is it possible they can recover or up-regulate? My grandiose and cortisol thinking from my adolescence has destroyed mine beyond repair. What do we know or understand about this aspect of neurochemistry? And more-so can anything be done about it?

>>16805938 (OP)
There is no evidence that depression is the result of physical factors, especially regarding dopamine and serotonin regulation. UCL's study of decades worth of research recently confirmed what most innately understood anyway.

>>16805946
What is innately understood, at least to you? What seems innate to me is chemical theory, just based on simple up/down regulation and evolutionary mechanisms for novelty and survival. Not saying you're wrong but interested to your theory.

UCL's study was mostly about serotonin anyways, which I agree has little to do with depression. Dopamine is much much more likely the culprit.

>>16805938 (OP)
You haven't narrowed it down to 4chan? Stop coming here. You know this.

>>16805957
The culprit is not physical factors. You are depressed because your life sucks, or you think your life sucks, or you simply don't like stuff. If you want a chemical solution to these issues, there are plenty.

>>16805938 (OP)
I'd be willing to talk with you in detail about this OP, but not on 4chan. I cant bother with these eternal captchas. Drop a discord or smth.

>>16805938 (OP)
depression is not rly a disease of dopamine receptors, its rumination circuits forming in the prefrontal cortex, these are neural "devices", physical networks of neurons in your brain that reinforce negative thinking, sap the joy out of everyday things, make it hard to feel accomplished or proud of anything, etc. Depression is so challenging because the symptoms are natural in origin, caused by the person's prolonged suffering.

If you want to test this, take adderall, it will instantly and 100% cure your depression, but the effect is only temporary. And if you take it long enough, you will find that you can still feel depressed even on strong stimulants. Depression is about behavioral change translating to eventual physical change in the brain. SSRIs do not have a clear mechanism of action on depression, desensitizing serotonin causes paradoxical upregulation in some cases and in other cases it seems the emotional blunting is actually important. Probably because it causes altered signaling to other brain regions like the VTA, there's so much we just dont know about the very fine, biomechancial level desu, but the overall concepts are clear I think

>>16805938 (OP)
All mental illness is on a gradient of activity

Its just metabolic, entirely

>>16806178
I actually tried Adderall, but truthfully at any dose it made me feel worse. The best way I can describe how Adderall made me feel was zombified, I could just sit on the couch and stare blankly at the wall, very emotionally mute. and also easily irritated.

>>16806069
Please do

420cutupkids

>>16805938 (OP)
Our brains are made of gore octopoids making us SUFFER

>>16805946
bullshit. don't listen to this person. receptor downregulation IS a thing. the studies he cites are wrong, who gives a shit if they've done things for decades with the wrong premises.

Depression has always been a social problem

>>16805946
Psychologist here. FPBP.
The notion that something is fundamentally wrong with you is actually one factor that maintains the depressive symptoms. What's rumination gonna do for you if that assumption was true? It's actually keeping your from acting although the solution is pretty simple. Just do stuff and retrain your brain.

>>16812733
how do you do anything consistently if you were born with negative symptoms of schizophrenia but are not actually schizophrenic

>>16805946
Reference?

>>16815788
You just become right wing and go with the flow

>>16805938 (OP)
>As someone with depression for 5 years now, I've really narrowed it down to having to do with the sensitivity of dopamine receptors.
Reality punishes this delusional belief system with constant suffering.

>delete capitalism
>cure 90% of the depressed people

>>16818699
>the year is 1867+158
>real proletard reboogalution has never been tried
>capitalism as such doesn't even exist anymore
>hordes of "depressed" leftroons still blame it for their condition