Thread 16829102

>>16829102 (OP)
start punching doctors and the cures will come out real fast

What wold be the benefit of being immortal? Working until you never die, and never retire because you just don't die retirement can't be financed anymore?

>>16829102 (OP)
Just don't get old or die, bro.

>>16829102 (OP)
It's an extremely complex problem. But there are vast and growing number of partially effective therapies with many diverse mechanisms of action already. Bryan Johnson is on some of them, but PubMed knows about hundreds of times more.

>>16829254
if you arent good with money you arent smart enough to use this board

>>16829295
Do you mind listing a few search terms for the class anon?

>>16829364
>>16829102 (OP)

Rapamycin and lithium both seem promising based on actual clinical data. There are others with less data that look good in animals. But the unfortunate truth is that interpretation of preclinical data leads many, if not, most researchers to considerably different opinions about which drugs are the best. The best drug ever could be out there in the literature already, but without hard clinical data, it may or may not be a great idea to megadose it. Could also be that 99% of everything is shit and we'll find out that even the best looking drugs produce marginal effects in large segments of the population.

My personal opinion is that scouring the literature for stuff that sounds interesting and taking some poorly characterized 12 drug stack and hoping the effects synergize is not a very productive use of time or money compared to either directly contributing to basic biology by working in a lab or becoming a scientist, or getting filthy rich and funding basic biology. I think we really need more genuine, creative, and non-risk averse efforts to discover or engineer brand new therapeutics. The current paradigm of banking everything on small molecule drugs just isn't that exciting to me. I doubt any of them will ever get us more than an extra 10 healthy years at best.

>>16829379
let me introduce you to a fella by the name of jesus christ.

>>16829379
You don't need to "beat" entropy, this is a retarded argument. You could theoretically have machines or mechanisms that decrease the entropy of the human body while still leading to an overall increase in the entropy of the universe in the same way that you can keep fixing a car from 150 years ago. The laws of thermodynamics are perfectly compatible with the goal of life extension. The real issue is just that it's extremely complicated compared to fixing a car and we don't know how to do it yet. Your pessimism is somewhat warranted, but for completely incorrect reasons.

>>16829102 (OP)
Immortality would unironically destroy society very quickly

>>16829397
No shit, that's why the elites would try to hold onto it and keep it a secret from everyone else for as long as possible.

>>16829364
>Do you mind listing a few search terms for the class anon?
Here are some pretty hot ones right now...
>senescence"
>"SASP"
>"senoprotein"
>"senolytic"
>"anti-aging"
>"maximum lifespan"
>"all-cause mortality"

>>16829379
This has nothing to do with entropy. The human body isn’t a closed system and there are animals out there that can live to 500 so it’s not physically impossible

>>16829454
Bump

>>16829102 (OP)
Immortality is morally indefensible.

Anons in Agartha don't age...
How will you live forever if you believe in aging?
It doesn't make sense.
Aging is punishment for sin (i.e. limiting yourself with doubt, and negative beliefs)

>>16829254
>What wold be the benefit of being immortal?
Not dying

>>16830899
Morality is an invention of schizo philosophers and delusional religiousfags; it has no rightful place in bioethics.

Life-extension technology is imperfect but already in R&D, and efforts to stifle it should be crushed; any regulations on it should be flouted.

>>16829102 (OP)
dying seems pretty much resolutive in stopping the aging process

>>16829254
You can either live forever or die. Really the first one isn't an option but even theoretically, those are the only two possibilities. If you don't wanna live forever, but you don't want to die, tough luck.
If between those two you pick death, you can find a tall building in your area and save some time.
>inb4 "natural death"
>inb4 "when my time comes"
It's just organ failure. You still die, and you still die NOW. Putting a problem off to the future (not a real thing) is just coping.

>>16829102 (OP)
>Still no cure for aging
if you want to live forever, you have to die young

>>16829102 (OP)
A ycombinator poster figured it out
>Death is in part an evolutionary advantage. The thymus of humans self atrophy in order to kill the elderly.
>I am one of the only transhumanist on earth to know that the thymic hormone thymalin restore thymus function and increase lymphocite T production by 680% and that this effect has been tested to lead to a 410% reduction of all cause mortality in humans
https://news.ycombinator.com/item?id=31376662
https://youtu.be/ET6yUgGTRGo?si=n2PaHjxvG-o9ofhu

>>16833991
You don't even ACK-shilly need thymalin to start thymusmaxxing...
>Bidirectional effect of ecdysterone on thymocyte volume regulation and proliferation
>https://www.sciencedirect.com/science/article/abs/pii/S0039128X25000947
Just like the shit with DWS's schizo plants, it's a pretty cool discovery that probably has significant lifespan extension benefits but it's not actually quite some magic cure for aging.

>>16831626
You enjoy one of the easiest and most carefree existences of any human that has lived on this planet thanks to the toil of thousands of ancestors who died in pain.

You haze ZERO (0) right to use up the resources and take up the space that would deny future humans a chance at existence.

>>16834162
>You haze ZERO (0) right to use up the resources and take up the space that would deny future humans a chance at existence.
Most humans don't even deserve it, and populations are collapsing anyway. If amortality becomes a real problem, we'll finally colonize to space or start sterilizing people if it actually gets bad.

>>16829102 (OP)
aging prevention is easy, just gene edit embyros so their telomerase never deactivates. have fun with your gigaturbocancer though

>>16834269
>implying telomere shortening is anywhere close to the whole aging process, or even remotely clinically relevant
>2025

>>16829254
>being alive when we finally find a theory of everything and get to know the fate of the universe
>being alive when we colonize other systems and finally encounter alien spaceships

surely none of this interests you?

>>16829102 (OP)
We are working on it asshole, but we have just barely mapped the causes, there are approaches for attacking a few, but we need to develop new purpose made biotechnology methods.
Also we are slowed down by grifter assholes like degray and sinclair.

>>16836138

Both are just work so no.

>>16836242
nigga you're doing work (in the physics sense) by fucking existing already, embrace it

>>16830899
People don't die from old age though. They die from ailments like heart disease, cancer, dementia etc associated with old age. Medicine has been trying to fix ailments since it existed. Jesus went around healing peoples ailments. Not to mention the average human lifespan is like double what it used to be and in the future will likely keep on doubling from medical advancements.

>>16834162
You can still have kids if you live longer. There's already tons of work being done on renewable and sustainable power, food, water, everything. People can still die if they're immortal so people will have to keep having children. I doubt we'll see true immortality for a very long time anyway if at all

>>16836167
>but we need to develop new purpose made biotechnology methods.
>Also we are slowed down by grifter assholes like degray and sinclair.
Many anti-aging interventions can be found just from repurposing current food/drugs/supplements; like Sinclair was co-author on a recent paper identifying the GSTA4 enzyme as a Yamanaka mimetic, and there is other research on acai berry extracts inducing it.

De Grey seems to have just str8 grifted for decades tho.

>>16829379
>babies are born with the age of their parents

>>16830899
>you have to die because I say so
great ethics you got there son!