Here is a over 200 hours save statics with 2000 active mod with 1400 active plugins. Many mods were deleted, added and updated (even the ones with "requires new save" warning) during gameplay, installed many LL mods and other sex mods along with experimental and alpha stuff. (using SLP+ and OSTIM) Also running with 50k animations.

2 scripts stuck
108 unattached instances
62 undefined elements
Save file size increased to13mb from 5mb
Crashes clearly increased but still can play without problem, these crashes almost happens randomly.
Still getting 60 solid fps.

Basically i didn't give a fuck about but ofc i was careful with mods, there a couple mods that fucked me and had to revert saves but most mods were fine.