I'm playing AIRL with a character who got hit by a breast enlargement curse before the adventure started. I specified that it makes her movements extremely unbalanced and she has trouble dealing with it, and it's funny seeing the game give her penalties and describing her flailing over the weight of her tits in battle. To make sure I don't just die instantly I'm playing on the 'adventure' difficulty that gives a +20 to every roll, so she's sort of got plot armor that usually makes things work out anyway even if she gets "-15 (massively unbalanced due to enormous breasts)" with funny descriptions in most physical checks.