Not Skyrim but oblivion years ago in college. One of my roommate and I loved the “potion of disbelief” because it’s funny to think that you can just not believe in magic and it actually hurting less. The character was Breton, hand to hand only, any alcohol found in a chest/crate must immediately be consumed, and most armor specifically has enchantments to resist/negate magic. It was fun to imagine a drunk hobo running around punching wizards going “magic isn’t real dumbass” while being transported to literal different dimensions, seeing lighting and fireballs being shot at him and other creatures manifesting from thin air to attack him