This cripple talk is a decent excuse for me to share a wheelchair story from my Rogue Trader game. Also contains what OP might deem "storygaming". In this instance, it turned out pretty well.

>Be the party's spymaster-type character, high Fellowship, massive brain
>Decide to get an even massiver brain by installing some brain doohickey cybernetic
>Ask the party's resident tech priest to install it
>About as hard a failure as one could get, I can't remember how exactly he screwed up that hard but it was bad
>Offer the lobotomite's player a few options as a consequence for the botched brain surgery: suffer facial paralysis (penalising his Fellowship rolls), paralysis of the legs, or lock himself out of getting the brain upgrade permanently
>Seeing as politicking and deception were his bread and butter anyway, not combat, he relinquishes his kneecaps

From here on he basically became a Professor X crossed with Baron Harkonnen type character. It was actually pretty cool, he was always the guy to cut deals with the major movers of the campaign and plot their eventual betrayal, relying on being underestimated. When he came into possession of a Fear rating much later, he invested a bit into more cyber gizmos to let him indirectly control his legs. When a fight broke out, he'd basically stand from his cripple throne and scare the shit out of the enemy.

Fun ass game. Great character.

On that note, the 40k games actually featured a full on combat wheelchair all the way back in a Dark Heresy adventure. We didn't use this, of course, I just think it's pretty stupid and funny.