If Owlcat does another 40K CRPG, I expect it to be Imperium Maledictum or Only War or Wrath and Glory with inqusiton involvement.
It seems Owlcat gravitates towards this in 40K as Rogue Trader feels more like a Dark Heresy game than a Rogue Trader game. You mostly investigate stuff like chaos and genestealer cults, xeno plots and even work for a lord inqusitor chasing a mystery rather than being focused on rogue trader politics, space adventures, trading, colonizing and aquiring resources or xeno artifacts etc. The only thing is the scale, 70% of the plot with the power level lowered would fit better in Dark Heresy by miles.