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6/28/2025, 10:49:16 AM
>>16708550
The dopamine/norepinephrine (DA/NE) theory of ADHD is well supported. Individuals with ADHD often have many abnormalities in genomes related to DA/NE synthesis, re-uptake, and receptor sensitivity. Each mutation on its own is insignificant, and actually quite common in healthy individuals, but the disorder arises when the patient has a maladaptive amount of mutations.
The attention span of the human population follows a normal distribution. The doubt of whether ADHD is "real" usually stems disagreements/confusion over what level of distractibility constitutes a disorder. American doctors who are sloppy/frivolous when diagnosing and short form social media usage artificially skewing our perception of what a "normal" amount of impulse control is.
At the end of the day, a person's executive functioning skills exist on a spectrum, and getting stuck on defining what degree of dysfunction constitutes a loosely defined label is kinda pointless. If a person feels that this hypercomplex system that demands a hundred decisions per day to function is unbearable, they should have the right to seek help from a relatively safe family of chemicals.
>I've not seen any research with conclusive evidence any of them are guaranteed to work
Everyone's neurobiology is different. Certain ADHD meds don't work for some people because they have a different DA/NE imbalance. For example, a person with a severe dopamine deficiency and a mild norepinephrine deficiency might find Dexedrine more effective than Adderall. The anon earlier who said that only Lisdexamfetamine worked was probably for this exact reason.
>>16708535
ADHD is more than just an inability to focus, it's cognitive dysfunction that often prioritizes short term gratification (gaming for example) over long term goals. "attention-deficit" is kinda a misnomer as individuals with ADHD often exhibit increased amounts of focus on tasks they do enjoy. They don't lack attention, they misdirect it.
The dopamine/norepinephrine (DA/NE) theory of ADHD is well supported. Individuals with ADHD often have many abnormalities in genomes related to DA/NE synthesis, re-uptake, and receptor sensitivity. Each mutation on its own is insignificant, and actually quite common in healthy individuals, but the disorder arises when the patient has a maladaptive amount of mutations.
The attention span of the human population follows a normal distribution. The doubt of whether ADHD is "real" usually stems disagreements/confusion over what level of distractibility constitutes a disorder. American doctors who are sloppy/frivolous when diagnosing and short form social media usage artificially skewing our perception of what a "normal" amount of impulse control is.
At the end of the day, a person's executive functioning skills exist on a spectrum, and getting stuck on defining what degree of dysfunction constitutes a loosely defined label is kinda pointless. If a person feels that this hypercomplex system that demands a hundred decisions per day to function is unbearable, they should have the right to seek help from a relatively safe family of chemicals.
>I've not seen any research with conclusive evidence any of them are guaranteed to work
Everyone's neurobiology is different. Certain ADHD meds don't work for some people because they have a different DA/NE imbalance. For example, a person with a severe dopamine deficiency and a mild norepinephrine deficiency might find Dexedrine more effective than Adderall. The anon earlier who said that only Lisdexamfetamine worked was probably for this exact reason.
>>16708535
ADHD is more than just an inability to focus, it's cognitive dysfunction that often prioritizes short term gratification (gaming for example) over long term goals. "attention-deficit" is kinda a misnomer as individuals with ADHD often exhibit increased amounts of focus on tasks they do enjoy. They don't lack attention, they misdirect it.
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