The only time I've thought it would be interesting to be type 1 diabetic in a video game, and not just in real life, was playing Project Zomboid.
And that was simply as a "fuck you" mode. Like, every fridge has 1-2% chance of containing insulin. Go to long without insulin and you'll die from ketoacidosis.
Double whammy, add coeliac mode too, forcing you to look at ingredients listings on food.