i don't watch much anime and i don't think i could choose one manga to name it as my personal goat. Kanoe Yuuko is my eternal waifu but i wouldn't call TOxA the goat, maybe something like akira, blame, bakemono, there's a lot of great manga.

If i had to choose one anime, i think i'd choose Madoka. 2 reasons being it's a really great, emotional story and i love it, it does everything right. and second being that normoids will never understand it.

pic only vaguely related