After wasting a LOT of time today trying to get the lightx2v gradio app working, then the comfyui wrapper, and both failing, I tried just using the lora in my usual wan 14b i2v fun camera workflow - it works great. Yes there is quality loss - it looks a little fried and oversharpened, but it's 3x as fast, so to me that's an OK tradeoff.
I'm using about 20GB VRAM with the lora, so regular 4090 users can definitely use this.