I know there's literally less than 0% chance of this ever happening but if deadlock became a genre, then I wish they would make an arcanum deadlock clone. I could get interesting with how magic and technology interfere with eachother, so you wouldn't just have to think about abilities and items, you would also have to consider the fact that magic spells would fail around machines, and guns would break when near magic.
At the very least it would create battles that feel different than the overused 'spam stuns and damage until enemy dead' or 'heal until enemy dead' strategies in most mobas.