>>714029985
I'd argue yes; it's a more advanced prosthetic but a prosthetic nonetheless. DMC5 just took advantage of using his missing arm to introduce new gameplay mechanics, and that's what games should do. Your hero's unique traits should inform how they play. I also remember in Sly 3, Bentley was in a wheelchair so they used that for unique platforming options.
Unless you mean Jensen, in which case my answer's still yes. I never played DE but I know he was injured pretty badly in a terrorist attack. His arms were visibly fully cybernetic so I assume at least those were amputated.