>>713912359
Blasphemous 2 has a giant censer as one of the weapons you can pick from the start.
Dead Space games have Contact Beam, although you get it later in the game. You can bring it into NG+.
Warrior in Dragon's Dogma gets Arc of Deliverance skill, you might have seen some webms.
All monster hunting games have some fuck off huge sword class, but obviously doesn't end monsters in one hit.
In Hammerfight you can wreck just about anything with a few solid flail hits, and it's the most kinetically pleasing thing you'll experience until we get brain jacks.
Shotty and stake gun in Painkiller fit the bill, and are universally available. Especially cool detail is how stakes ignite from air friction after certain distance, and do double damage.
In Unreal you get shock rifle quite early, and the combo deletes just about anything. You can also load up rocket launcher with up to 8 missiles at once, and Flak Cannon is a beast later on.
All Souls games can be played with some huge 2-handed club.
Renegade Ops lets you grab different subweapons, and slow railgun absolutely wrecks, plus one of the characters can transform his car into a huge stationary gun.
The werewolf in Contra Hard Corps gets a set of weapons that is a bit unwieldy, but
absolutely melts bosses.