I got to brainstorming a but too hard in another thread, but I think there's real potential in an mlp x-com like game with the main premise being preventing a changeling invasion in a city like Manehatten, similar to protecting the main city in X-com Apocalypse. Keeping the masses calm to prevent full on panic and city shutdown. Tech focuses on weeding out where changelings are nesting and infiltrating the populace as well as countering their mutations and evolutions as you progress and hinder their plans.
Also it gave me an excuse to break out the aseprite and do this little mock up of a player unit base