I'm pretty close to my goal of getting all the achievements. Most of the ones I have left are just certain story choices, like be heretical, but a couple have eluded me. I'm pretty sure I scanned all available planets, and the internet has a lot of conflicting information on how to get the "at home amongst the poor" achievement. I'm pretty sure I've talked my way through several fights too. The grimdark one took two playthroughs of grimdark mode to finally pop, so there is some amount of inconsistency with these, and I'm afraid some others might be affected.

I also still have not gotten the one for doing a romance lol.
I also didn't know that subduing the pit required the player to be a psyker. I brought Idira and Jimmy along in my playthroughs and passed all the checks and always wondered why that one didn't pop. So I'll be a psyker in my next playthrough.