I've been doing more testing with samplers.

Gradient Estimation consistently wants to add more detail to an image, but can seem rough / noisy / cluttered. It seems like it might be good for photorealistic gens, or if you know you're going to do inpainting or editing to clean things up and wouldn't mind fixing extra details.

Kohaku_LoNyu_Yog is the opposite and by far the smoothest sampler, smoothing out a lot of detail and causing a flatter look. This seems really good for more of a 2D animation look like cartoons or flat anime.

SEEDS 3 DP and SA-Solver also both seem good. SEEDS 3 might take the longest but also seems to result in quality gens. SA-Solver seems similar but favors more saturated / vibrant colors.

Full res test: https://files.catbox.moe/s9pxdd.png