I really like the 3 way karma system in Rogue Trader, having Heretic, Iconoclast, and Dogmatic, and having your potential allies and entire quest lines opened/closed based on where you sit. The admin is actually fun, having to make decisions like one of those choose your own adventure books. In one of these, I ended up needing to decide what to do with a bunch of refugees from one of the worlds in my protectorate, and chose to resettle them on another planet. The next page told me that I'd destroyed the workers' livelihoods on that planet, sent the place into poverty and ultimately it ended in mass bloodshed. I thought "heh".