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7/12/2025, 6:55:52 AM
>>76363013
Sheeit, I'm getting so motheruckin' sharp with experimental chemo research, I might just start again for a new challenge.
> Identification of natural flavonoids as novel EGFR inhibitors using DFT, molecular docking, and molecular dynamics†
>Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that causes different types of cancers on its overexpression or mutation and rearrangement or amplification of the EGFR gene. Inhibition of EGFR is one of the popular cancer treatment techniques.
>Rhamnocitrin derivative Tupichinols E (10) obtained from southern Chinese plant Tupistra chinensis shows the best results. Tupichinols E has 1.4 times more binding ability than osimertinib (third-generation EGFR tyrosine kinase inhibitors (TKIs)). The compound binds at the exact position of osimertinib in the crystal structure of EGFR and has similar poses.
>https://pubs.rsc.org/en/content/articlelanding/2022/nj/d2nj00389a
Sheeit, I'm getting so motheruckin' sharp with experimental chemo research, I might just start again for a new challenge.
> Identification of natural flavonoids as novel EGFR inhibitors using DFT, molecular docking, and molecular dynamics†
>Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor that causes different types of cancers on its overexpression or mutation and rearrangement or amplification of the EGFR gene. Inhibition of EGFR is one of the popular cancer treatment techniques.
>Rhamnocitrin derivative Tupichinols E (10) obtained from southern Chinese plant Tupistra chinensis shows the best results. Tupichinols E has 1.4 times more binding ability than osimertinib (third-generation EGFR tyrosine kinase inhibitors (TKIs)). The compound binds at the exact position of osimertinib in the crystal structure of EGFR and has similar poses.
>https://pubs.rsc.org/en/content/articlelanding/2022/nj/d2nj00389a
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