Ran the first session of Dark Heresy, 6/7 players are newcomers so they're on board with my schizophrenic modifications.
The moment the tech adept realizes how fucked his strength bonus is he tries to kick in a 3m thick plasteel door (SB 7, most of it via good Synthmuscles).
The pyromancer tries to pocket bits of a mutated warp touched corpse and uses his powers to light cigarettes during warp transit.
And the defacto leader adopts a shoot-on-sight policy for anything that looks funny.
All in all, i think i lucked out.