The main conflict of 2049 is just too silly to take seriously. There's no reason to believe that replicants couldn't be made to breed or that they couldn't just keep scaling up factories. The guy seems to be able to pop out new replicants quickly and kill them off wantonly since they're trivial. There's no reason to think the top of the line breeding model would die giving birth its first time. And what worth is the replicant child when it's locked away in an isolated room for thirty years?

And since replicants were banned and Wallace had to fight so hard to get them allowed back on Earth, there's no reason to continue making them indistinguishable from humans rather than extremely obvious. Give them blue skin. Two glowing eyes. An irremovable giant serial number around their neck. It's retarded to make it so they blend in and you need specialized police to track them down, beat them up, and force them to look a certain direction to check their number. They can still fulfill the same purpose of carrying heavy shit, fighting wars, slaving away, and prostitution yet be obviously robots.