>>5014916
>Dogs with the multidrug resistance 1 (MDR1) gene have severe and life-threatening reactions to some common drugs. Approximately three of every four collies in the United States have the mutant MDR1 gene.
>Neuronal ceroid lipofuscinosis (NCL), also known as Batten disease, is a group of neurodegenerative disorders that affect the nervous system. NCLs are a type of lysosomal storage disorder, and symptoms vary between forms but often include a combination of: Vision Loss, Dementia and Epilepsy
>Trapped neutrophil syndrome (TNS) is a common fatal genetic autosomal disorder that has only been found in Border Collies. With this condition, the bone marrow produces the neutrophils normally but they are not transferred to the blood where they are needed to fight illnesses. With such a low immune system, most puppies become sick and die by the time they are about four or five months old.
This is horrific. The fact that a dog breed can have this many genetic and nuerological disorders is just astonishing.