>>105985543
>CPU
Fine.
>Cooler
An upgrade would mainly be for noise or PBO. As you can see a 420mm AIO would only net you another 2-3% nT performance at 100% fan speed.
>Mobo
It's okay in that it can run the CPU but I think you might want PCIe5 to remove any potential bandwidth limitations on GPU compute. This will depend on your specific software suite. There are B*50E boards priced under your current one so this shouldn't mean spending more.
>RAM
Bad choice. Both in selection and configuration. If you absolutely must have 4xDR DDR5 it should at minimum be a matched kit and ideally Hynix 24Gb M-die. Expect it to require manual tuning in any case. If you can get away with 96GB, do so.
>SSD
Fine. Could maybe shave some here if you price shop on the day. I assume you have a NAS or something for bulk storage? If not you will need some.
>Case
Good at present. Change it if you get an AIO instead.
>PSU
Fine. Price-shop on the day.