People don't think about this a lot, but Portuguese people and Spanish people are quite apart from one another, and Portuguese people are quite "insular" in relation to Europe.
Historically we've been enemies in the scope of larger Euro conflicts, mostly because Spain sided with France and Portugal sided with England.
When not fighting these euro-wars both countries held great diplomacy between each other.

Nowadays it's all within the greater E.U., and I'd say we get along with Spain as well as we do with France, Germany, etc.