>Nature Scientific Reports volume 15, Article number: 26889 (2025)
>Comparative efficacy of topical interventions for facial photoaging: a network meta-analysis
>https://www.nature.com/articles/s41598-025-12597-0
>Safety analysis indicated tretinoin had the most favorable profile, whereas tazarotene and glycolic acid had higher adverse event risks. Isotretinoin and tretinoin emerged as the most balanced treatments across efficacy and safety.
As a heavy glycolic acid user who never had an adverse event, I think this is calcium hydroxide peel neutralization skill issues.