Prologue set at Site B of the Jurassic World park introduces the D-Rex, a mutant hybrid who escapes amid the chaos of the first Jurassic World film.

A few years after Jurassic World: Dominion, most dinosaurs died out due to modern Earth climate being inhospitable, except for a range in the equator.

ScarJo is a mercenary hired by a pharmaceutical company man to accompany a retrieval team to Site B; the company needs the DNA of the three largest dinosaurs because their abnormally strong heart structure could be the cure to heart disease. ScarJo’s mother died of heart disease, but she is indifferent to the possibility of saving lives and only cares about the money. ScarJo ropes Mahershala Ali and his boating/merc team into the expedition and the company man brings along a paleontologist trained by Alan Grant.

Meanwhile, a father, his two daughters, and his one daughter’s boyfriend are sailing across the ocean when the Mosasaurus capsizes their boat. The mercenary crew hears the distress signal and Mahershala makes his crew go pick the family up because he lost his own daughter and bonds with the younger sister. A pack of Spinosaurs attacks the mercenary boat, killing the one member of the crew who was a douchebag.