as a new player you should pretty much always check your perks first to decide if theres more value in rerolling to potentially get something better than spending it on spells or wands in the shop. you have to learn how to make that judgment call. here i will just take toxic immunity because its easily one of the best perks, any time you see an immunity (or one of the immunities that come with a downside) you pretty much just insta snap it up and be happy that you didnt have to reroll
this changes when you start looking for more specific things but as a beginner just learn the perks and try to gain some sort of understanding of whats good. immunities are basically always good, some are better than others. id take explosion immunity over the rest, maybe id order them something like
explosion>melee>electric>fire>toxic