When humans seek to understand the nature of reality, some fundamental "sanity," the result is almost always madness.
Because what is being sought is nothing less than the ultimate power.
Narrow-minded dipshits think that manipulating others is power. Knowledge is true power, and the ultimate knowledge is a basic accurate model of reality and one's place within it. This is the power that has evaded human grasp for all of history.

Want to see someone become completely unhinged? Merely ask them "what do you think the nature of reality is?"