In a recent interview, Samanta Beart, Karlach's VA, talks about how she considers Karlach a person who knows can intimidates others and how she wants to put them at ease with a joke or a kind word, and how she discussed this with Ray Stevenson, the actor who plays Titus Pullo in Rome as they're both "gentle giants".
I love how this game interacts with other media not only for inspiration but also for talent, each person involved can be seen to have put in their own effort beyond what was required to refine their craftsmanship and it shows in the result.