>>542463479
If you want to go DPS Cyrene go for her E1 no question about it. It's pretty much a requirement for the playstyle since it gives her nuke a 720% damage multiplier. Push comes to shove you can always cope with the BP lightcone.
I've seen showcases of people coping without Evernight and using Tribbie, so I suppose Tribbie E1 is an alright replacement if you don't have Evernight (Cyrene's literally getting almost 200% True DMG). Hyacine... I'd say is pretty much a must. Even if only E0S0. Ica generates so many ult stacks for Cyrene, and she gets so many buffs from Tribbie + Cyrene that she basically becomes a subdps. The only cope close to Hyacine is Dan but his ult stack generation is pretty lame and he deals no damage. THAT SAID, V3 buffed E1's ult stack generation so we'll see how it affects her and her teammate replacements.
Also unrelated but for anyone curious, V3 changed Cyrene's nuke damage% from 950% to 1140%. So +190%. And the ult stack generation got buffed
