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Glutamine is a major nutrient to maintain intestinal barrier function in animals and humans. Depletion of glutamine results in villus atrophy, decreased expression of tight junction proteins and increased intestinal permeability. Moreover, glutamine supplementation can improve gut barrier function in several experimental conditions of injury and in some clinical situations. Furthermore, preventive effects of glutamine in experimental models of intestinal injuries have been recently reported.
https://pubmed.ncbi.nlm.nih.gov/27749689/
https://pubmed.ncbi.nlm.nih.gov/25972430/
Glutamine and the regulation of intestinal permeability: from bench to bedside - PubMed
Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant Irritable Bowel Syndrome - PubMed
This is another thing to think on. N-Acetylcysteine (NAC) is a supplement you can get anywhere. It's use is to boost glutathione which is the body's main antioxidant and a regulating chemical. It reduces inflammation and has a large number of positive effects. It's being tested as treatment for a number of diseases
https://en.wikipedia.org/wiki/Glutathione
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234027/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423092/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/
https://www.mountsinai.org/health-library/supplement/cysteine
