>>96274866
A heist of the Svalbard Seed Vault (now operated by Biotechnica) to get your hands on non-licensed pre-modification seeds for a rival corporation.
Arasaka's solar-powered, self-sustaining and self-replicating naval mines make naval trade impossible...except for the depths of the Polar Night, where the extended period without sunlight forces the mines in the arctic circle to temporarily enter sleep mode to conserve their batteries. This opens up a two-week window for the Thelas Nation to move heavy equipment from the Arctic Archipelago to Europe and Russia (or vice versa). The corporations know this too, of course, and are hunting the party as they act as escorts through the Arctic Archipelago before the sun returns and the mines reactivate.
An escort mission to protect a nomad tribe as it migrates to summer quarters among the tree farms/temperate forests of the post-global warming Northwest Territory might be a good break mission, and a chance for edgerunners who have only seen lifeless desert to see life as it used to be for their grandparents, and even possibly bring back a non-cloned pet like a squirrel or raccoon.