Honestly I think half the reason New Vegas is so loved is because of all the western themed shit. In a post apocalyptic wasteland, there's really only two good aesthetics:
>Wild west
>Slavic Europe
Fallout has always been American, so we will likely never get the latter (and you could just play Stalker for that anyway), so honestly FO5 should just drop us somewhere else out west and double down. Like come on did anyone really wanna go to fucking BOSTON for FO4? Even if we aren't doing a western aesthetic that's like one of the worst fucking locations they could have picked. At least drop us in Miami Florida or some shit so we can get crazy Florida Man™ ghouls, radioactive hurricanes, and mutant gators.