Probably Lewis Trondheim, creator of Kaput and Zosky. The show and comic were a bit formulaic, but it was pretty charming and had a wonderful sense of style and surrealism. It probably has my favorite "generic space/sci-fi" style second only to Futurama, and I'm a big fan of its comfy simplicity. Also I'm a HUGE fan of characters with underbites and overbites.

(And no, I'm not that one guy who most people associate with this show when it's posted on this board, Birchy I think his name was.)