Rumour is that Safia is an imposter. She's an ancient vampire who replaced the real Safia, who is found shriveled up in a coffin somewhere. Intuitively, fake Safia would have to be a Tzimisce using high level fleshcrafting. There's no proof of this, and it could just be schizo nonsense. But... it's kind of an obvious twist if you think about it. She's a little... too friendly.