There are several levels at which you can approach the play of Frenopolis.

These are the basic levels which can be done by simply reading the card text.
-Card advantage - Just plain being able to do more stuff than the other player by having more cards
-Stat advantage - Having stronger cards (big number win) than the other player. This approach relies heavily on being able to conduct combat unimpeded.

This is an advanced level which can be done by knowing the color pie. It can be mixed with all other approaches
-Elemental advantage - With this approach, the number or strength of your cards is less important than which elements you have control over, and from what elements.

For example (Manifest cards), if you have an Entity (Fire) that can remove Structures (Earth), you can have control of the Fire element through the Earth element.

If you have an Entity (Fire) and a Meme (Air) that can remove or negate Structures (Earth), you have control of the Earth element from the Fire and Air element.

If you had control of every element from every element, you would have an unbreakable board. Due to how the color pie is constructed and the interference of the other player, this is very hard to do without being very clever and adaptive.