I feel like the age of exploration and its great expeditions doesn't have a lot of games. Which is weird because it's kind of tangential to a lot of popular rpg themes, and it's well covered by movies, computer games and books. You can run it in games like whfrpg or d&d, but it doesn't quite fit. And there are pirate games, but that's a whole different theme really, same with western. The traits I'm looking for is that the players are a part of an expedition that's well equipped, but isolated (by potentially months of travel), part of a group, but don't have their family there, in a place where the societal structure of their home country is far away, but maybe the captain is the local authority, and there's still a sense of identity that's reinforced by the fact that the people they meet will be very "other" etc. You can do a lot of classic tropes like exploring lost temples, searching for hidden treasures, fighting jungle beasts, etc, but crucially not with a band of d&d hobos.
Considering how afraid a lot of publisher seem to be about colonial era themes it's unlikely that such games will ever become mainstream, but I think it's kind of weird that the theme wasn't explored more before. In a fantasy world you can sidestep or subvert some of those themes.