>>16752624
>"synthetic" organs with improved functionalities and (would be feasible today) direct immune editing through modified differentiated PBMCs.

This has been a sticking point for me in sci-fi and why having some kind of purely mechanical prosthetic of a limb or organ will never make sense as a desireable long term solution.

That said, even a smooth brain like myself is aware the body can't use anything it doesn't have "instructions" for so if you had some kind of augmented organ would you have to somehow adapt the body to make it learn how to use the organ and its features or would that happen as the updated genetics of the new organ interact with the body?