>>542559090
Emps kills Lazy with an explosion if Lazy takes the artifact from Shart in Shart's origin story.

Lazy just takes the artifact to the creche and dies in the Zaithisk. Even if Emps saves her from the Zaithisk, she's still sitting in the creche and potentially still loyal to Vlaakith since no one convinced her otherwise, so the artifact simply falls into Vlaakith's hands again. The Emperor is killed by githyanki agents, but the Absolute cult is probably destroyed by Vlaakith's army, with massive collateral damage. We see the brain simply kill red dragons easily, so the city is destroyed and the gith suffer massive causalities, but an actually concerted effort by the gith could probably do it.

If Shart doesn't have someone in the party to make her touch grass, then she becomes a justiciar, kills all the allies from act 1/2, and brings the artifact to Viconia. This outcome might still end with the brain's destruction however, since the Sharran cult wants the Absolute cult dead too. So in a roundabout way, Shart could win the game. But it's not really a "good" ending, for her or the city.

Gale simple wins the game in act 2 with his nuke.

Wyll, Minthy, Jaheira, Karlach, and Halsin have the highest chance of winning the game in the traditional way.
However, Karlach might lose control when she sees Gortash and rush in and die, which would deliver the artifact to him and result in the cult winning.

Minsc never escapes from doppleganger control in time to stop the plot, and the cult wins.

None of this really matters however, since if the game's characters are not successful, Elminister just solves the problem at the last minute. But it's still fun to think about.