Got some new hits on potential calorie restriction mimetic pathways...
>Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
>https://www.biorxiv.org/content/10.1101/2025.08.04.668533v1.abstract
>Using longitudinal plasma proteomics analyses in humans achieving 14% CR for 2 years, we identified that inhibition of the complement pathway is linked to lower inflammaging. The protein C3a (and its cleaved form) was significantly lowered by CR, thus reducing inflammation emanating from three canonical complement pathways.
>Notably, long-lived FGF21-overexpressing mice and PLA2G7-deficient mice exhibited lower C3a in aging. Specific small molecule-mediated systemic C3 inhibition reduced inflammaging, improved metabolic homeostasis, and enhanced healthspan of aged mice.

>β-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes
>https://www.degruyterbrill.com/document/doi/10.1515/biol-2022-0095/html
>Effect of High-Intensity Interval Training and Portulaca Oleracea Extract Supplementation on FGF-21 Level and Insulin Resistance in Rats with Non-Alcoholic Fatty Liver Disease
>https://publish.kne-publishing.com/index.php/SSU/article/view/12806

>The cardioprotective mechanisms of draconis sanguis: An integrated network pharmacology, bioinformatics, and experimental validation study
>https://www.sciencedirect.com/science/article/pii/S2095754825000547
>DS reduced the expression of Pla2g7 (P = .0009), NLRP3 (P = .003), interleukin-18 (P < .001), and interleukin-1β (P = .004) mRNAs in vivo.
>The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
>https://onlinelibrary.wiley.com/doi/full/10.1155/2020/5850865
...TIL I've been eating some potential CR mimetics I didn't even know did that.