Thread 76481200

Hi /fit/izens, if you've been following the old cold rich dude floundering in the mortality disruption industry, he's cycling his metformin now! Wow, such very /sci/entific discovery, he is surely close to figuring this whole thing out now and getting his speed of aging to 0.0, right guys?
>Salidroside alleviates cardiomyocyte senescence by activating the AMPK-mediated signaling pathway
>https://link.springer.com/article/10.1007/s10735-025-10546-9
>A biocompatible anti-aging gel mask prepared with sappanwood extract and sodium carboxymethyl cellulose, exhibiting antioxidant and antibacterial properties
>https://www.sciencedirect.com/science/article/abs/pii/S0141813025071454
>Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise
>https://www.mdpi.com/1422-0067/26/15/7573
>Ageless Creatures: Molecular Insights into Organisms That Defy Aging
>https://journals.4science.ge/index.php/GS/article/view/3955
>Black rice-anthocyanin enhanced antioxidants and extended lifespan by inhibiting the PI3K/AKT/mTOR pathway
>https://www.sciopen.com/article/10.26599/FSHW.2024.9250180
>Malic enzyme 1 reverses cardiomyocyte senescence in a nitric oxide-dependent manner
>https://www.sciencedirect.com/science/article/abs/pii/S0891584925008640
>Does Nigella sativa supplementation improve cardiovascular disease risk factors? A comprehensive GRADE-assessed systematic review and dose-response meta-analysis of 82 randomized controlled trials
>https://www.sciencedirect.com/science/article/pii/S104366182500307X
>A Comprehensive Review of Pathological Mechanisms and Natural Dietary Ingredients for the Management and Prevention of Sarcopenia
>https://www.mdpi.com/2072-6643/15/11/2625
Anyone else on here deep in the gerontology literature with better ideas? Any personal experience modulating myogenic regulatory factors, or is this way too abstruse lol nerd shit for all you tren-heads?

>>76481200 (OP)
Hi pharma anon (marry me).
As far as AMPK-stuff goes, exercise should have it covered (that and PGC-1a, histone acetylation, ubiquitin stuff you talked about before.)
For mTOR, sirolimus/everolimus should be better than a supplement.
I do need to read through these studies but those are my initial thoughts reading the titles.

>>76481281
>(marry me)
Post MAOA, OXTR and AVP genotype.
>For mTOR, sirolimus/everolimus should be better than a supplement.
Those have some nasty side effects, but Bryan Johnson's copper skill issues were *part of* the reason for his infections.
And uh, here's some less boomer leads on muscle building...
>Effects of Ulmus macrocarpa Extract and Catechin 7-O-β-D-apiofuranoside on Muscle Loss and Muscle Atrophy in C2C12 Murine Skeletal Muscle Cells
>https://www.mdpi.com/1467-3045/46/8/491
>Kazinol-P from Broussonetia kazinoki enhances skeletal muscle differentiation via p38MAPK and MyoD
>https://www.sciencedirect.com/science/article/abs/pii/S0006291X14021500
>Amaranthus as a potential dietary supplement in sports nutrition
>https://www.tandfonline.com/doi/full/10.1080/19476337.2024.2375253
>Ficus lindsayana Leaf Extract Protects C2C12 Mouse Myoblasts Against the Suppressive Effects of Bisphenol-A on Myogenic Differentiation
>https://www.mdpi.com/1422-0067/26/2/476
>Protective Role of Ethanol Extract of Cibotium barometz (Cibotium Rhizome) against Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
>https://pmc.ncbi.nlm.nih.gov/articles/PMC10573348/

>Attenuation of oxidative stress and artificial wound closure in C2C12 myoblasts induced by sequential extracts of Boerhavia diffusa
>https://academic.oup.com/jpp/article-abstract/70/1/111/6121746
>Chemical constituents of the Ajuga multiflora bunge and their protective effects on dexamethasone-induced muscle atrophy in C2C12 myotubes
>https://www.tandfonline.com/doi/abs/10.1080/14786419.2022.2115491
>Effects of Alnus japonica Hot Water Extract and Oregonin on Muscle Loss and Muscle Atrophy in C2C12 Murine Skeletal Muscle Cells
>https://www.mdpi.com/1424-8247/17/12/1661
>Dioscorea nipponica extracts enhance recovery from skeletal muscle atrophy by suppressing NF-κB expression
>https://www.sciencedirect.com/science/article/pii/S1756464620303339
>Rosa rugosa promotes muscle hypertrophy and prevents atrophy in C2C12 myoblasts
>https://link.springer.com/article/10.1007/s10068-024-01803-w
>CAPTCHA:JW0RX

>>76481287
>>76481678
>Those have some nasty side effects
Yeah, but drugs are better behaved than supplements, I would think. I find it weird you keep posting about supplements instead of drugs that have (presumably) linear pharmacokinetics.
Amaranth is interesting though.
And as you presumably know, a lot of this in vitro stuff doesn't carry over to in vivo, which is again why I find drugs more interesting because pharma companies are willing to throw money at in vivo studies.

> drugs are better behaved than supplements, I would think.
Not always an accurate generalization; it's quite variable from compound to compound. Prescription drugs do tend to be better-researched in general, but sometimes you'll find random supplements that have their same mechanism(s) of action with even greater efficacy or fewer side effects.

>>76483508
>sometimes you'll find random supplements that have their same mechanism(s) of action with even greater efficacy or fewer side effects.
99% of the time there is someone willing to extract the active ingredient and sell it raw, which lets you helpfully treat it just like a drug

>>76481200 (OP)
Imagine caring this much about some e-celeb
Unironically get a life

>>76483699
Some of them it's fine to get a relatively unrefined product though, so long as you've got enough active ingredient total and no nasty impurities. Also,some plant might have a bunch of different molecules with different bioactivities and you're not just after one.

>>76483718
desu I only care about Bryan enough to vaguely track what he's trying in terms of interventions; it's the "Don't Die" mission he's half-assing that I'm more interested in, and trying to do better than him at.

Also I take issue on principle with trying to target ubiquitin pathways since it seems too basic to not fuck something up inadvertently. Even going for ERR or something a little more upstream seems like it'd have a much better chance at not killing you.

>Huangjing Yangji Decoction Ameliorates Skeletal Muscle Aging and Mitochondrial Dysfunction Via Sirt1/Atf5-Mediated Mitochondrial Unfolded Protein Response
>https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5377053

>>76484136
>it's the "Don't Die" mission he's half-assing that I'm more interested in, and trying to do better than him at.
actually doing it or just spamming articles on 4chan?

Over 80% of the papers you're posting are fresh papers off the press from chinks, how are you getting the full text? You work at a university or something? And most of it is in cell lines, meaning that there's probably a 5% chance anything useful happens in vivo.
>>76484776
Trve

>>76481200 (OP)
How do I start learning about this?
Obviously there's a bunch of probability and stats stuff, plus how to read studies, plus a lot of medical background knowledge. I do plan to learn that.
What do I read for that?

And for the time being, I just need someone to tell me what to do.

>>76485048
>Over 80% of the papers you're posting are fresh papers off the press from chink
>anon doesn't know Dementia Daddy Donald killed most Burger research for being too "woke"
>2025

>>76485062
>How do I start learning about this?
Start with learning the basics on the physiology of the aging process, duh?

>>76485223
>Start with learning the basics on the physiology of the aging process, duh?
Le sassy 4chan post

>And for the time being, I just need someone to tell me what to do.
I need a list of recommended supps in the meantime while I get learned. I don't want to wait through 2 years of studying before starting a stack.

Nigga with all this medical obsession you could probably start a blog or youtube channel and make money. But yet you are spamming it on an anonymous anime forum.

>>76485062
Start learning about GH-related pathways and insulin/glucagon, that'll take you most of the way
>>76485223
>>anon doesn't know Dementia Daddy Donald killed most Burger research for being too "woke"
>>2025
Again, a lot of the stuff you're posting is just not very high quality. It's hard to make actual actions based on the papers because they're so detached from reality the results may as well be fake.

>>76485231
Exercise is going to be the best thing for now, everything else has side effects that you need to know how to handle

>>76485231
Start by reviewing the leaderboard of the Revuvenation Olympics and look up all the stuff the top people are taking on PubMed. You'll find both some snek oilz and evidence-based supplements.

>>76486365
>everything else has side effects that you need to know how to handle
Not literally everything, but it is important to learn about stuff like NAC chelating copper and boron when you're taking it long-term.

>>76486433
>Start by reviewing the leaderboard of the Revuvenation Olympics
Isn't this literally a rigged leaderboard?
>Not literally everything
Figuring out what that is requires knowing what you're doing, which anon doesn't.

>>76486635
>Isn't this literally a rigged leaderboard?
Yes it is where Bryan Johnson always comes out on top despite his terrible small molecule skill issues, but this doesn't make all the supplements that they all take fake science. Only somewhat under half of it is fake science, lol.

one does not simply duct tape wrinkles

>>76483718
we're going to defeat death

New crop of useless chinkjeet cell assays incoming! KEK. If Bryan even looked at a tenth of this shit, he'd be mogging way harder.
>Isowighteone attenuates Vascular Calcification by Targeting HSP90AA1-Mediated PI3K-Akt Pathway and Suppressing Osteogenic Gene Expression
>https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1636883/abstract
>Novel exosome-like vesicles from Dendrobium officinale: Unraveling a pioneering extraction protocol and their skin anti-aging potentials
>https://www.sciencedirect.com/science/article/pii/S2773041725000277
>Polyalthia longifolia var. angustifolia thw.: a review of ethnobotany, phytochemistry, pharmacology applications and future prospects as a green anti-aging agent
>https://link.springer.com/article/10.1007/s13596-025-00839-5
>Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans
>https://www.nature.com/articles/s41538-025-00456-1
>Co-Supplementation of Policosanol and Banaba Leaf Extract Exhibited a Cooperative Effect Against Hyperglycemia and Dyslipidemia in Zebrafish: Highlighting Vital Organ Protection Against High-Cholesterol and High-Galactose Diet
>https://www.mdpi.com/1422-0067/26/16/7669
>Potent in vitro Antioxidant, Antimicrobial, and Antidiabetic Effects of a Polyherbal Mixture: Evidence from 3T3-L1, β-TC6, and C2C12 Cell Line Studies
>https://www.phcogres.com/article/2025/17/3/105530pres20252220
>Microsorum Membranaceum (D. Don) Ching Protected Dexamethasone-Induced Sarcopenia by Targeting Protein Degradation and Synthesis Pathway in C2c12 Cells and C57bl/6 Mice
>https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5371525
>Diet-Derived Advanced Glycation End-Products (AGEs) Induce Muscle Wasting In Vitro, and a Standardized Vaccinium macrocarpon Extract Restrains AGE Formation and AGE-Dependent C2C12 Myotube Atrophy
>https://www.mdpi.com/2076-3921/14/8/900

When are you going to post in vivo studies? In rats or humans

>>76488834
i'm a "really smart guy" but i still don't know what 'in vivo' means. does it mean irl? in your body? too lazy to google it tho, plz spoonfeed.

if it does mean irl why don't you just say that? no need to start speaking spanish for no reason.

>>76490402
It's latin for "in [that which lives]", the term "in vivo" is a term of art in medicine
Yes it means in an actual body, not in isolated cell lines (that would be "in vitro", "in glass")

>>76488834
NIH ITP is the leader on mouse lifespan studies currently, but they don't publish that freakin' often compared to all the chinkjeet cell assays: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/publications

Here's one of them chinkjeet C2C12 myoblast assays that at least is confirmed to swole-ify mice: >Fragrant olive (Osmanthus fragrans Lour.) flower extract attenuates dexamethasone-induced muscle atrophy through stimulation of PI3K/Akt pathway in C2C12 myotubes and C57BL/6 mice
>https://www.sciencedirect.com/science/article/pii/S1756464625000362
Also FYI, assay hits on a pathway conserved between species with a <500 dalton small molecule have a decent chance of in vivo activity usually.

Do they ever do pig lifespan studies?

>>76491790
>>76491790
>Here's one of them chinkjeet C2C12 myoblast assays that at least is confirmed to swole-ify mice
Neat, thanks anon
>Also FYI, assay hits on a pathway conserved between species with a <500 dalton small molecule have a decent chance of in vivo activity usually.
Fair enough, but I mean moreso to see if there are any showstopping side effects like cancer or hepatotoxicity.

>>76491790
interdasting

>>76491790
>Exercise endurance was evaluated by measuring running distance and time on a motorized 5-lane treadmill with a shock grid
why don't human gyms incorporate the shock grid?

>>76492346
>why don't human gyms incorporate the shock grid?
Shit, my home gym has one; you're just using some gym with shit-tier tech that probably only got red light therapy last year.
>cough cough Planet Fatness.

>>76481200 (OP)
>>Ageless Creatures: Molecular Insights into Organisms That Defy Aging
>>https://journals.4science.ge/index.php/GS/article/view/3955
neat

>>76481200 (OP)
holy shit, i will become immortal, thank you anon

>>76481200 (OP) (OP)
>>76493882
this for your efforts cutie https://desuarchive.org/fit/thread/69346906/#69346906

Got some new hits on potential calorie restriction mimetic pathways...
>Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging
>https://www.biorxiv.org/content/10.1101/2025.08.04.668533v1.abstract
>Using longitudinal plasma proteomics analyses in humans achieving 14% CR for 2 years, we identified that inhibition of the complement pathway is linked to lower inflammaging. The protein C3a (and its cleaved form) was significantly lowered by CR, thus reducing inflammation emanating from three canonical complement pathways.
>Notably, long-lived FGF21-overexpressing mice and PLA2G7-deficient mice exhibited lower C3a in aging. Specific small molecule-mediated systemic C3 inhibition reduced inflammaging, improved metabolic homeostasis, and enhanced healthspan of aged mice.

>β-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes
>https://www.degruyterbrill.com/document/doi/10.1515/biol-2022-0095/html
>Effect of High-Intensity Interval Training and Portulaca Oleracea Extract Supplementation on FGF-21 Level and Insulin Resistance in Rats with Non-Alcoholic Fatty Liver Disease
>https://publish.kne-publishing.com/index.php/SSU/article/view/12806

>The cardioprotective mechanisms of draconis sanguis: An integrated network pharmacology, bioinformatics, and experimental validation study
>https://www.sciencedirect.com/science/article/pii/S2095754825000547
>DS reduced the expression of Pla2g7 (P = .0009), NLRP3 (P = .003), interleukin-18 (P < .001), and interleukin-1β (P = .004) mRNAs in vivo.
>The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
>https://onlinelibrary.wiley.com/doi/full/10.1155/2020/5850865
...TIL I've been eating some potential CR mimetics I didn't even know did that.

>>76494176
nigga how many information you have wow

>>76494176
if the only way to live forever is to go full skellington then you can just let me die. i knew you were going to bring this up sooner or later. you couldn't wait until after i had breakfast?

>>76495200
The whole idea of CR mimetics is you can (theoretically, eventually, with enough of them) eat like a fatass while getting longevity benefits of fasting.

Last year Kombucha was identified as possibly being one: https://www.medicalnewstoday.com/articles/drinking-kombucha-tea-probiotics-help-reduce-fat-mimicking-fasting

Several other have been in clinical trials: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.717343/full

>>76495922
eating my way to immortality seems a modest proposal

>>76481200 (OP)
OP is the best poster on this board, even better than me and that fat blond powerlifter

>>76494176
You'll type up all this degenerate bullshit but you won't stop eating grainsludge. Grim. Transhumanists are lolcows.

>>76496289
Bryan Johnson does *real* calorie restriction and even TRT couldn't get him above "victim weight" so calorie restiction mimetics are a lot more attractive than starving yourself and shooting up boomer drugs, which clearly doesn't f'n work to keep muscle mass on in combination.

I was telling my friends at work about Bryan Johnson and they were already aware of his existence. How could such a thing be possible? I thought he was just a no-name e-celeb. These are cool young people, mind you, not boring old Boomers.

>>76498214
there was a Netflix documentary about him

>>76498228
was at the bouldering gym last night and this image could not be more relevant, made me kek

>>76481200 (OP)
Are you the schitzo who posted in those threads on /sci/ where a dude claimed to have cured everything including cancer and circumcision with apigenin, tributyrin and tumeric?

>>76498214
I saw his face on a cover of some print magazine at a store last year.

>>76498597
That was DudeWearingShoes or DWS. I'm actually an oncology-focused biotech trader with a way better-looking chest. Yamanaka factor tech isn't fake, but it isn't going to make you immortal or cure absolutely every disease. It does, however, approximately double the lifespan of mice as of a couple years ago...
>Aging (Albany NY). 2023 Jul 12;15(13):5966–5989. doi: 10.18632/aging.204896
>Chemically induced reprogramming to reverse cellular aging
>https://pmc.ncbi.nlm.nih.gov/articles/PMC10373966/

>>76498228
>>76498235
glows really do shoot thoughts into your head, though. that image is soft disclosure, and some of them have a (((religious))) need to tell you what they are doing to you (so it's your fault if you don't stop them). they are also painting themselves as the cool pepe spooks when nothing could be further from the truth. the meme takes the focus away from how evil and invasive it is to inject thoughts into people and instead moves the conflict from 'free men versus glowies' to 'men versus women.'

the image has always bothered me for those reasons. trust me, i am a meme expert.

>>76500150
Bro you can test this by getting a bunch mu metal shielding or sandbags and foil or whatever and blocking all sorts of radiation. The glowies spread their propaganda through media, not some weird kind of radiation.

>t. spent a lot of time in very radiation-hardened environments doing singals engineering and did not notice alternations in thought patterns beyond the calming effect of being somewhere with good acoustic shielding from normie background noise.

>>76500686
they absolutely shoot people with millimeter and scalar waves to influence behavior. they can make you feel angry and violent if they want to. this is just the tip of the iceberg.

i can see that i've activated your defenses against this topic but this really isn't the place to discuss it. i just don't like that meme is all.

>>76500150
take your medication.

>>76501943
The glowies do have real radiation-based "area denial" "non-lethal weapons" and shit...
>https://jifco.defense.gov/Future-Intermediate-Force-Capabilities/Active-Denial-Technology/
But you'll pretty much only see these operating around protests/riots, they are not *subtle* (cause a fair amount of pain) and even buildings/foil block/reflect their radiation fairly well.

>>76488834
Because they are rare.
And they also have the issue where they confuse testing and hypothesis, which means they are also not verifying if their chemistry is working correctly.

>>76495200
Going full skellington stresses your entire body system once its done recycling the bloat.
Which is why you need the drug cocktail, but its a very complicated system, where the goal of healing and the goal of reducing systematic wear might even be conflicting.

>>76503481
>Going full skellington stresses your entire body system once its done recycling the bloat.
Bryan Johnson learned this one the hard way and totally bogged himself. Picrel.

>>76503481
>where the goal of healing and the goal of reducing systematic wear might even be conflicting.
But it can definitely be done with the right kind of research. For example, bromelain after Bryan's fat troonsfer would have helped dissolve his scar tissue, necessitating fewer laser treatments.

>>76503240
again, i gave you an opportunity to drop the subject and you persist with your subversion. those area denial weapons were vehicle-based and they have been common knowledge for 30 years now. i am talking about small convert weapons that use electromagnetic waves (or we can call it 'radiation' if you insist) to interfere with people's though processes. they can be a small device that fits into a backpack or- more seriously- they can be emitted from a smartphone. so, anyone following you around (zersetzung, community harassment, gangstalking) may also be shooting millimeter waves through your fucking brain. this is obviously not good for you and if you suspect this is happening you should get away from the perp as quickly as you can. don't bother telling the police because they won't believe you.

the best thing to do to the people who do these things is to photograph and record them doing it.

are we finished?

>>76503579
*thought processes

>>76503240
again, i gave you an opportunity to drop the subject and you persist with your subversion. those area denial weapons were vehicle-based and they have been common knowledge for 30 years now. i am talking about small covert weapons that use electromagnetic waves (or we can call it 'radiation' if you insist) to interfere with people's thought processes. they can be a small device that fits into a backpack or- more seriously- they can be emitted from a smartphone. so, anyone following you around (zersetzung, community harassment, gangstalking) may also be shooting millimeter waves through your fucking brain. this is obviously not good for you and if you suspect this is happening you should get away from the perp as quickly as you can. don't bother telling the police because they won't believe you.

the best thing to do to the people who do these things is to photograph and record them doing it.

>>76503596
>2025
>4chan so schizo it thinks the neighborhood Karen recording her kids' swim meet is a glowie gangstalker using 6G millimeter wave voice2skull thought-hijacking technology.

this might be the most tryhard shilling on 4chan right now

there is no way someone could legitimately give a fuck about whoever this is and continually post about it. its just advertising.

>>76503721
now you're trying to get the thread banned because there's information in it that you don't want to get out. which is the whole reason i wanted to drop the subject in the first place because i knew that you would do this. just give up now and i promise not to bring up child sex trafficking.

>>76503596
>zersetzung, community harassment, gangstalking

>>76503721
At least upgrade to some azelaic and salicylic acid chemical peels, if not even glycolic, Bryan. You're walling too hard.

>>76503596
holy fucking schizo lmao
what're you doing that's so important that the glowniggs need to deploy zersetzung on your ass nigga

the jeets be up in the spectrofluorimetric testing fighting Sleepy Joe/Derpy Donnie syndrome better than the Burgers these days...
>Unravelling Anti-Glycation, Anti-Amyloid, Anti-Inflammatory, and Antioxidant Properties of Selected Medicinal Plant Extracts: A Multifaceted Novel Anti-Aging Approach
>https://journals.sagepub.com/doi/full/10.1177/1934578X251363375
>Among the 12 plant extracts examined, S. trilobatum hydroalcoholic (Sth) extracts significantly reduced the three AGEs content (Malondialdehyde, pentosidine, and crossline) as compared to glycated BSA (p<0.0001). Moreover, A. sinensis hydroalcoholic (Ash) extracts inhibited the self-aggregation of Aβ25-35 fargments by 87%, exhibiting significant anti-amyloid activity and a possible function in preventing protein aggregation linked to neurodegenerative conditions like Alzheimer's disease (AD).

>>76505224
Jeets are dysgenic af, you on drugs.

>>76505237
>Saar is not downregulating his interleukin 17s and inhibiting his kruppel-like factor 15 expressions with the turmeric curry
>2000 and the twenty-05

>>76504029
He looks fine in that picture. Everyone looks real sharp when you photograph them midsentence on an airplane. The really impressive picture is the naked kettleball snatches though. I joined his fanclub when I realized he mogs 95% of /fit/.

I feel like taking a million different plant extracts does not seem like a good solution for the aging issue. You know when people complain that doctors only treat symptoms and not the underlying causes of issues. A lot of this stuff seems the same to me but for aging. I feel like a better solution would not be so piecemeal for each sign of aging.

>>76506898
Look up the Krebs cycle.
What he and a lot of other biohackers is doing is to try to overtune that, and a lot of other cycles the body do.

>>76506898
>I feel like a better solution would not be so piecemeal for each sign of aging.
You can find some interventions here and there that seem to have fairly "global" effects like GlyNAC, but really micro-managing gene expression away from a senescent phenotype will probably be ultimately proven far more effective than even cycling Yamanaka factors.

>>76481200 (OP)
Fear of death is pussy behavior. I want big hot muscles to fuck cutie twinks and then I gladly welcome death. Will probably kill myself in several years.

>>76505440
>>76507095
The funny thing about Bryan Johnson's body is that literature says the lowest all-cause mortality is actually in the BMI 25-30 range; bro fell for the CR meme and got too skinny.

I personally think BMI 29+ is getting unhealthy even if it's all muscle, but this "durr keep it 18-24 for longevity" is kinda B.S.

>>76507115
What does that have to do with not being a pussy bitch afraid of death? Literally all I want is to fuck twinks and then die.

>>76507232
Literally getting bigger muscles is correlated with not dying until you hit powershitter range, lmao.

>>76507115
>all the literature
The doctors that push shit like that are always fat. You can't read 'all the literature' you've got to read the stuff that's actually correct. BMI, for instance, what if you're dying of cancer? The best thing to do is fast and starve those tumors into remission. Autophagy. The body feasts upon itself. I think that the loss of appetite caused by chemo is probably more effective at ridding your body of cancer than the radiation.

Sometimes it seems to me that the BMI chart is actually just an elaborate troll by the government. It helps no one lose weight. Obese people look at it and think 'yep, I'm fat' and thin people just get mad when you tell them to eat moar.

I think that the lower and middle range is probably the best place to be on the BMI chart and don't think 'underweight' is as much of a concern as fat American doctors make it out to be. Look at Japan- their BMI chart is different from ours. They think lower weights are optimal for health and longevity and 25 or higher is considered obese. I think that their standards are more realistic. We're not talking about muscle men here, by the way, just normal people. The BMI chart is meaningless to bodybuilders.

>>76507831
>The best thing to do is fast and starve those tumors into remission.
No, the best thing to do is get your tumor DNA sequenced, figure out which pathways drive its growth, then eat foods that specifically downregulate/inhibit those pathways in addition to any synthetic chemo(s) you can find that aren't shit-tier.

There aren't any magic cures for cancer, but you can overwhelm its signalling pathways with the right kinds of chemo cocktails in a lot of cases.

>>76507392
Like I said, I just want them in the short term, even if it means deadly steroids. I do plan to kill myself within the next ~3 years.

>>76508325
>even if it means deadly steroids
Jebus cwithe, just CTRL+F "C2C12" higher up in this thread and lrn about the next generation of myogenic regulatory hacking BTFO'ing the boomer shit.
>press F to pay respks

Anon when are you making a wiki
I was first poster in this thread but got busy and didn't backread

>>76508442
>swole scientists naming molecules after zyzzbro

>>76508442
>>76509662
>SMI1 has been renamed ZYZ384
Based salute