>>717323145
Mass Effect. I am kind of cheating since I did do one playthrough with FemShep, but that was 1 out of like 10 playthroughs I've done of the trilogy. I just vastly prefer how Shepard sounds as a guy and it doesn't help that Garrus and Wrex are the only cool male companions while everyone else is either shit, forgettable or doesn't join until 3 (Javik and Huge McBeefcake).

On the opposite side of things, I almost always play as a girl in Pokemon because the boys look boring as fuck and I only doubled down on that when they added customization options and made all the male clothing options shit.