>>714450957>literally doesn't name any run ending anti-synergiesJudging by the webm you posted you're literally a retard for justifying playing like a mong and bumrushing shit
>Curse of the blindJust like every other curse you're supposed to play around it
>BUT I NEEEEED MY TREASURE ITEM / BOSS ITEM / SHOP ITEM / DEVIL DEALliterally learn when you should take and when to skip
you do not NEED to take every item
>D100 roll or any items that also work like itthen... charge your D4/D100 and re-roll your build
>getting your path blocked by a shitty itemdrop your trinket / pill / card and abuse the item hold animation frames retard or quit out and reload to get at the door
there is literally ZERO situations where you're actually blocked by an item through natural procgen, you're a retard for proccing pedestal spawning items in the wrong place
>>714451554until indie devs learn that what makes isaac good is rewarding for experimentation and knowing the game
it's very easy for them to fall under the trap of having synergies when they're dogshit and shallow