>>724855324
The first Mom boss takes place on floor 6. The next final boss Mom's Heart/It lives takes place floor 8 and you need to kill it, what, 10-15 times for unlocks and opening path forward. After that floor 9 opens to Sheol and Cathedral. Killing each floor's boss 10 times opens Dark Room and the Chest. Angel Room Angel statues become bosses and killing 2 angels grant access to Mega Satan in Dark Room and Chest.
New challenges include Boss Rush (killing floor 6 boss in 20 minutes) and Hush (killing floor 8 boss in 30 minutes). The game adds Greed and Greedier mode requiring you to beat the modes with each character and fill the Greed Machine to 1000 coins for unlocks.
Repentance adds alt route (Sewer-Mines-Gehenna-Rotten Womb) and new final boss Mother. Beating Mother opens route to Home and new bosses Dogma and the Beast with Ultra Harbringers.
Then after normal routes there's Void and Delirium.
Multiple dozens Challenges, each character getting tainted versions, secrets and unlocks