>>725147089
Give or take five runs for the underworld path, then 5 runs for the surface path. You'll likely have to do another 10-20 runs though before you actually see a victory or get the dialogue that unlocks end game incantations needed to reach credits. That, and the curse that Eris puts on you makes blazing through early runs a nightmare on purpose.
So, probably about 15-30 hours if you're on top of things and decent at the game/lucky with boons. There's an epilogue as well, but it's genuinely nothing of value. That, and the requirements are obnoxious because you have to progress dialogue with characters, some of which are only 3/4s of the way through a run, that will stack up dialogue related to entirely separate quest lines. I had to do a run to speak with a certain boss at least 10 or 15 times before they said a thing I needed to progress. Shit's obnoxious how its designed.