>>725457691
It's more likely that it will be closer to what the Xenoblades are doing, 95% of the story is stand alone and the last 5% involves the other games but isn't absolutely needed for a complete understanding of it.
For example if a sequel to 33 involves the writers, you could see Renoir and/or Clea be major players of the enemy faction, people who played 33 would know their backstory but people who didn't would require it to understand their roles.