>>11983253 (OP)
Of course, it already happens with companies like Retro-Bit and Columbus Circle. Probably Limited Run too despite their shit quality control. They have companies like Capcom and Rare collaborating through these kinda companies, and I doubt they are going through all the legal work for nothing.
For maximum profits, it would have to be someone like Nintendo and be on a platform that is easily accessible/still kept by many. If they had decided to manufacture actual official StarFox 2 carts in addition to the SNES Classic addition including it, they could have definitely reached that goal. Same goes for official EarthBound Beginnings carts, though probably less so, since Japan retro gamers would have less of a reason to buy it.
As far as a completely NEW, original title? I'm sure it would be possible, but it would need to be advertised and hyped up more. You put out a Nintendo Direct where Miyamutoid comes out and shows off a completely brand spanking new game he has decided to make for the GameBoy, and you could easily reach that goal. Hell, something like Earthion will probably sell pretty decently once the Genesis version is ready to go.