>>5069420
Ok, that sounds promising. So one person in their lifetime can breed noticeable docility and easy handling into a line.
Yeah, I specifically want to use wild mice because fancy and lab mice seem far too inbred at this point. Either that, Or mix every variety of fancy/lab mouse together with wild mice.
Also the experiment probably shouldn't be a completely closed system. So add new mice from outside the experiment each generation to keep inbreeding at bay.
Longevity selection would be a straightforward manner. Only allow males of a minimum age to breed, (no males under the age of 2 years etc).
Docility around humans would be easier to select for that you'd think too. I've heard that simply choosing very young individuals that approach the hand without fear works well. (An old technique that was used for dogs).
Selecting for intelligence is something that nobody has ever successfully done. But to be fair, I don't think anyone has specifically had that as a goal.
With dogs it has always been hyper-specific, often repetitious skills. Rather than some global intelligence.
The mice should definitely work for their food as wild mice do. Because most of their brain is devoted to finding food.
Selecting for intelligence is the tricky bit.
