>>106566786 (OP)
It's only possible if you are running 32-bit Windows 10. Windows 11 doesn't have a 32-bit version, so it's impossible. Also, you need to modify the .exe headers to make it run.
>>106567499
In case you don't know what OTVDM is, it is the 16bit compatibility layer for 32 bit Windows, but for 64 bit instead.
e.g. Windows 64bit > NTVDM > OTVDM > Your 16 bit app
>>106566786 (OP)
Only if OTVDM is installed on that system because whatever exe you might make in OTVDM will be 16bit and require the win16 subsystem which doesn't exist without it.