A setting in which a supervillain similar to Syndrome or Senator Armstrong actually won and gave every person on Earth superpowers, whether through some crazy tech or a magic ritual. Instead of like in MHA were most superpowers are basically completely useless, every one on the planet is at least a street level super powered individual. This obviously completely changed society, with Superheroes from before now having to come to terms with the fact that everyone is now mostly able to fight their own battles and supervillains having to become far more subtle since every civilian is capable of thwarting their plans just through brute force and swarm tactics.
Also the supervillain who gave everyone superpowers basically became a beloved figure by the public overnight, causing them to win the U.S presidency despite not running or even being an American citizen.
